Rohon P, Faber E, Divoka M, Rozmanova S, Friedecky D, Jarosova M, Indrak K. A significant proportion of patients with chronic myeloid leukemia and suboptimal response according to European Leukemia Net criteria have excellent prognosis without treatment change. Biomed Pap Med Fac Univ Palacky Olomouc (2011); doi: 10.5507/bp.2011.059.
IF (2010) = 0.716
Faber E, Friedecký D, Micová K, Rožmanová S, Divoká M, Jarošová M, Indrák K, Adam T. Imatinib trough plasma levels do not correlate with the response to therapy in patients with chronic myeloid leukemia in routine clinical setting. Ann Hematol. 91 (2012) 923-9.
IF(2010) = 2.600
Cizkova M, Bouchalova K, Friedecky D, Polynkova A, Janostakova A, Radova L, Cwiertka K, Trojanec R, Zezulova M, Zlevorova M, Hajduch M, Melichar B. High lapatinib plasma levels in breast cancer patients: risk or benefit? Tumori. 98 (2012) 162-5.
IF(2010)=1.014
Micová K, Friedecký D, Faber E, Adam T. Isotope dilution direct injection mass spectrometry method for determination of four tyrosine kinase inhibitors in human plasma. Talanta. 93 (2012) 307-13.
IF(2010)=3.722
Janecková H, Hron K, Wojtowicz P, Hlídková E, Barešová A, Friedecký D, Žídková L, Hornik P, Behúlová D, Procházková D, Vinohradská H, Pešková K, Bruheim P, Smolka V, Stastná S, Adam T. Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders. J Chromatogr A. 1226 (2012) 11-7.
IF(2010)=4.194
Zrostlikova J, Binkley J, Wojtowicz P, Adam T. Application of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry in human metabolomic studies. J Anal Chem 66 (2011) 1333-1340. IF(2010)= 0.650
Wojtowicz P, Dostálová E, Adam T. Analýza biologického materiálu dvojrozmernou plynovou chromatografií. Klin Biochem Metab 20 (2012) 38–40.
Votava F, Kožich V, Štastná S, Chrastina P, Adam T, Friedecký D, Vinohradská H, Kracmar P, Chovancová B, Balašcaková M, Piskácková T, Macek M, Gaillyová R, Valášková I, Švagera Z, Truellová I Novorozenecký screening v Ceské republice. Postgraduální medicína. 12 (2010) 785 – 792.
Mahon FX, Molimard M, Foryciarz K, Davies A, Fava C, Friedecky D, Schleyer E, Schuld P, Guilhot F. Imatinib Blood Level Testing – Current Perspectives and Key Questions. European Haematology. 4 (2010) 59–64.
Bouchalová K, Cížková M, Cwiertka K, Trojanec R, Friedecký D, Hajduch M. Lapatinib in breast cancer - the predictive significance of her1 (egfr), her2, pten and pik3ca genes and lapatinib plasma level assessment. Biomed Pap Med Fac Univ Palacky Olomouc. 154 (2010) 281-288.
WOJTOWICZ, P., ZROSTLIKOVA, J., ŠTASTNÁ, V., DOSTÁLOVÁ, E., ŽÍDKOVÁ, L., BRUHEIM, P. AND ADAM, T. Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry in Human Metabolomics. In B. SALIH. Gas Chromatography - Biochemicals, Narcotics and Essential Oils. Rijeka, Croatia: InTech, 2012, p. 236. ISBN 978-953-51-0295-3.
Kratschmerova, H. et al. Targeted metabolomics for diagnosing of inherited metabolic disorders. Clin Biochem 44, 520-520, doi:DOI 10.1016/j.clinbiochem.2011.03.035 (2011).
Bruheim, P., Kvitvang, H. F. N., Andreassen, T., Adam, T. & Villas-Boas, S. G. Highly Sensitive GC/MS/MS Method for Quantitation of Amino and Nonamino Organic Acids. Anal Chem 83, 2705-2711, doi:Doi 10.1021/Ac103245b (2011).
Baresova, A., Friedecky, D. & Adam, T. Analysis of Nucleotides in Dry Blood Spots. Chem Listy 105, 207-211 (2011).
Baresova, A., Friedecky, D. & Adam, T. UHPLC-TMS for simultaneous screening of numerous inborn errors of metabolism. Clin Biochem 44, 520-520, doi:DOI 10.1016/j.clinbiochem.2011.03.036 (2011).
Friedecky, D., Micova, K., Faber, E., Polynkova, A. & Adam, T. Flow injection analysis vs. ultra high performance liquid chromatography coupled with tandem mass spectrometry for determination of imatinib in human plasma. Clin Chim Acta 411, 1957-1962, doi:DOI 10.1016/j.cca.2010.08.014 (2010).
Faber, E. et al. Measurement of Trough Imatinib Plasma Levels in Patients with Cml Does Not Significantly Correlate with Treatment Response but May Be Successfully Used in Selected Patients for Dosage Adjustment. Haematol-Hematol J 95, 343-344 (2010).
Faber, E. et al. Imatinib dose escalation in two patients with chronic myeloid leukemia, with low trough imatinib plasma levels measured at various intervals from the beginning of therapy and with suboptimal treatment response, leads to the achievement of higher plasma levels and major molecular response. Int J Hematol 91, 897-902, doi:DOI 10.1007/s12185-010-0576-y (2010).
David, D., Faber, E., Micova, K., Indrak, K. & Adam, T. Hightroughput Blood Level Testing of Imatinib by Flow Injection Analysis - Tandem Mass Spectrometry. Haematol-Hematol J 95, 535-535 (2010).
Zidkova, L. et al. Oligodendroglia from ADSL-deficient patient produce SAICAribotide and SAMP. Mol Genet Metab 101, 286-288, doi:DOI 10.1016/j.ymgme.2010.06.014 (2010).
Adam, T., Wojtowicz, P., Zrostlikova, J., Kovalczuk, T. & Schurek, J. Evaluation of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the diagnosis of inherited metabolic disorders using an automated data processing strategy. J Chromatogr A 1217, 8054-8061, doi:DOI 10.1016/j.chroma.2010.09.067 (2010).
Tomkova, J., Friedecky, D., Polynkova, A. & Adam, T. Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes. J Chromatogr B 877, 1943-1945, doi:DOI 10.1016/j.jchromb.2009.05.005 (2009).
Zidkova, L. et al. Prefrontal cortex oligodendroglia cells from ADSL deficient patient produce SAICAR and SAMP. J Inherit Metab Dis 31, 158-158 (2008).
Tomkova, J., Friedecky, D., Vyskocilova, P. & Adam, T. ITPase activity in dry blood spots is comparable with that in fresh erythrocytes. Nucleos Nucleot Nucl 27, 656-660, doi:Doi 10.1080/15257770802143897 (2008).
Faber, E. et al. Imatinib Plasma Levels Correlate with Molecular Response in Civil Patients. Haematol-Hematol J 93, 219-220 (2008).
Faber, E., Friedecky, D., Micova, K., Adam, T. & Indrak, K. Determination of Imatinib in Plasma by High Performance Capillary Electrophoresis. Haematol-Hematol J 93, 442-443 (2008).
Vyskocilova, P., Hornik, P., Friedecky, D. & Adam, T. Spectral and electromigration characteristics of imidazole ribosides. Chem Listy 101, 250-254 (2007).
Pospisilova, D., Cmejlova, J., Adam, T. & Cmejla, R. Effects of leucine administration in diamond-blackfan anemia patients. Blood 110, 502a-503a (2007).
Friedecky, D., Tomkova, J. & Adam, T. Determination of ITPase activity by capillary electrophoresis. Clin Chem 53, 1164-1165, doi:DOI 10.1373/clinchem.2007.086058 (2007).
Adam, T. et al. Analysis of aminoimidazole ribosides by capillary electrophoresis - Diagnosing defects in second part of purine biosynthetic pathway. Clin Chim Acta 376, 184-189, doi:DOI 10.1016/j.cca.2006.08.020 (2007).
Adam, T. et al. Capillary electrophoretic method for nucleotide analysis in cells: Application on inherited metabolic disorders. Electrophoresis 28, 373-380, doi:DOI 10.1002/elps.200600262 (2007).
Adam, T. et al. Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway. Nucleos Nucleot Nucl 25, 1237-1240, doi:Doi 10.1080/15257770600894691 (2006).
Adam, T., Vyskocilova, P., Hornik, P. & Friedecky, D. Screening for defects in purine de novo biosynthesis by TLC. J Inherit Metab Dis 29, 129-129 (2006).
Adam, T. et al. Analysis of aminoimidazole ribosides by capillary electrophoresis - Diagnosing inborn errors of second part of purine de novo synthesis. J Inherit Metab Dis 29, 129-129 (2006).
Adam, T., Hornik, P., Vyskocilova, P. & Friedecky, D. Diagnosing AICA-ribosiduria by capillary electrophoresis. J Chromatogr B 843, 15-19, doi:DOI 10.1016/j.jchromb.2006.05.020 (2006).
Adam, T., Friedecky, D., Bednar, P. & Prochazka, M. Analysis of intracellular nucleotides by capillary electrophoresis - Mass spectrometry. Nucleos Nucleot Nucl 25, 1233-1236, doi:Doi 10.1080/15257770600894667 (2006).
Schneiderka, P., Vyskocilova, P., Hornik, R., Friedecky, D. & Adam, T. A simple screening method for defects in purine biosynthetic pathway. Clin Chim Acta 355, S240-S241 (2005).
Adam, T., Skopkova, Z., Hrabincova, E., Stastna, S. & Kozak, L. Molecular genetic analysis of SLC3A1 and SLC7A9 genes in Czech and Slovak cystinuric patients. Ann Hum Genet 69, 501-507, doi:DOI 10.1111/j.1529-8817.2005.00185.x (2005).
Adam, T., Hornik, P., Vyskocilova, P., Hlidkova, E. & Friedecky, D. Purine biosynthesis ribosides - Synthesis, spectral properties and HPLC analysis. Clin Chim Acta 355, S223-S224 (2005).
Adam, T., Hornik, P., Vyskocilova, P. & Friedecky, D. Analysis of aminoimidazole ribosides by capillary electrophoresis. Clin Chim Acta 355, S353-S353 (2005).
Adam, T. et al. Analysis of intermediates of purine biosynthesis pathway by capillary electrophoresis. Clin Chim Acta 355, S353-S353 (2005).
Kleparnik, K., Grochova, D., Skopkova, Z. & Adam, T. Detection of the major mutation M467T causing cystinuria by single-strand conformation polymorphism analysis using capillary electrophoresis. Electrophoresis 25, 57-64, doi:DOI 10.1002/elps.200305618 (2004).
Huskova, R., Chrastina, P., Adam, T. & Schneiderka, P. Determination of creatinine in urine by tandem mass spectrometry. Clin Chim Acta 350, 99-106, doi:DOI 10.1016/j.cccn.2004.07.007 (2004).
Huskova, R., Bartak, P., Cap, L., Friedecky, D. & Adam, T. Analytical derivatization - a tool for determination of orotic acid. J Chromatogr B 799, 303-309, doi:DOI 10.1016/j.jchromb.2003.10.068 (2004).
Frycak, P., Lemr, K., Adam, T. & Huskova, R. Diagnostics of some inherited metabolic disorders by mass spectrometry using modern ionisation techniques. Chem Listy 97, 93-100 (2003).
Adam, T., Lochman, P., Friedecky, D., Hlidkova, E. & Skopkova, Z. High-throughput capillary electrophoretic method for determination of total aminothiols in plasma and urine. Electrophoresis 24, 1200-1207 (2003).
Machova, L. et al. Prevalence of hyperhomocysteinaemia in subjects with ischaemic cerebrovascular attacks and a transitory attack resp - Pilot study. Cesk Slov Neurol N 65, 92-95 (2002).
Lemr, K., Frycak, P., Huskova, R. & Adam, T. Atmospheric pressure ionization mass spectrometry of purine and pyrimidine markers of inherited metabolic disorders. J Mass Spectrom 37, 1242-1248, doi:Doi 10.1002/Jms.389 (2002).
Adam, T., Lochman, P. & Friedecky, D. Screening method for inherited disorders of purine and pyrimidine metabolism by capillary electrophoresis with reversed electroosmotic flow. J Chromatogr B 767, 333-340 (2002).
Adam, T., Friedecky, D. & Bartak, P. Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism: A selective approach. Electrophoresis 23, 565-571 (2002).
Lemr, K., Adam, T., Frycak, P. & Friedecky, D. Mass spectrometry for analysis of purine and pyrimidine compounds. Adv Exp Med Biol 486, 399-403 (2000).
Friedecky, D., Adam, T., Sevcik, J. & Bartak, P. New techniques in diagnostics by capillary electrophoresis of hereditary disorders of purine and pyrimidine metabolism. Chem Listy 93, 528-532 (1999)
Adam, T., Sevcik, J., Svagera, Z., Fairbanks, L. D. & Bartak, P. Determination of adenosine deaminase activity in human erythrocytes by on-column capillary isotachophoresis capillary zone electrophoresis in the presence of electroosmotic flow. Electrophoresis 20, 564-568 (1999).
Adam, T., Friedecky, D., Fairbanks, L. D., Sevcik, J. & Bartak, P. Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism. Clin Chem 45, 2086-2093 (1999).
Svagera, Z., Adam, T., Bartak, P. & Sevcik, J. Determination of enzyme activities by capillary zone electrophoresis. Chem Listy 92, 673-675 (1998).
Bartak, P. et al. Study of cytokinin separation using capillary electrophoresis with cyclodextrin additives. J Chromatogr A 818, 231-238 (1998).
Adam, T., Sevcik, J., Fairbanks, L. D. & Bartak, P. Determination of purine enzyme activities in human erythrocytes by capillary electrophoresis. Purine and Pyrimidine Metabolism in Man Ix 431, 759-763 (1998).
Sevcik, J., Adam, T. & Sazel, V. A rapid and simple screening method for detection of orotic aciduria by capillary zone electrophoresis. Clin Chim Acta 259, 73-81 (1997).
Adam, T., Sevcik, J., Fairbanks, L. D. & Bartak, P. Determination of purine nucleoside phosphorylase activity in human erythrocytes by capillary electrophoresis. Journal of Chromatography B 698, 308-311 (1997).
Sousek, J., Adam, T., Valka, I., Guedon, D. & Simanek, V. Phenolics and alkaloids of Mediterranian Fumaria plants. Antioxidative effect of phenolic and alkaloid extracts. Chem Listy 90, 705-706 (1996).
Sevcik, J., Adam, T. & Mazacova, H. A fast and simple screening method for detection of 2,8-dihydroxyadenine urolithiasis by capillary zone electrophoresis. Clin Chim Acta 245, 85-92 (1996).
